Two types of colistin heteroresistance in Acinetobacter baumannii isolates
نویسندگان
چکیده
منابع مشابه
Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii.
Multidrug-resistant Acinetobacter baumannii has emerged as a significant clinical problem worldwide and colistin is being used increasingly as "salvage" therapy. MICs of colistin against A. baumannii indicate its significant activity. However, resistance to colistin in A. baumannii has been reported recently. Clonotypes of 16 clinical A. baumannii isolates and ATCC 19606 were determined by puls...
متن کاملGlobal Epidemiology on Colistin Resistant Acinetobacter baumannii
While colistin remains a last resort agent to treat multi-drug resistant Acinetobacter baumannii, resistance to colistin has been reported throughout the world. The resistance has been attributed to mutations in lipid A biosynthesis genes and point mutation in PmrAB-two component response regulator and sensor kinase system. The emergence of plasmid mediated colistin resistance (mcr-1), in multi...
متن کاملColistin-resistant Acinetobacter baumannii: beyond carbapenem resistance.
BACKGROUND With an increase in the use of colistin methansulfonate (CMS) to treat carbapenem-resistant Acinetobacter baumannii infections, colistin resistance is emerging. METHODS Patients with infection or colonization due to colistin-resistant A. baumannii were identified at a hospital system in Pennsylvania. Clinical data were collected from electronic medical records. Susceptibility testi...
متن کاملHeteroresistance to cephalosporins and penicillins in Acinetobacter baumannii.
Heteroresistance to antimicrobial agents may affect susceptibility test results and therapeutic success. In this study, we investigated heteroresistance to cephalosporins and penicillins in Acinetobacter baumannii, a major pathogen causing nosocomial infections. Two A. baumannii isolates exhibited heteroresistance to ampicillin-sulbactam, ticarcillin-clavulanic acid, cefepime, and cefpirome, sh...
متن کاملHeteroresistance to meropenem in carbapenem-susceptible Acinetobacter baumannii.
The characteristics of carbapenem heteroresistance were studied in 14 apparently carbapenem-susceptible Acinetobacter baumannii isolates. The MICs for carbapenems were determined, and the isolates were genotyped by pulsed-field gel electrophoresis (PFGE) and sequence typing (ST). Population analysis, testing of the stability of the heteroresistant subpopulations, and time-killing assays were pe...
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ژورنال
عنوان ژورنال: Emerging Microbes & Infections
سال: 2020
ISSN: 2222-1751
DOI: 10.1080/22221751.2020.1821584